9-13 July 2012
Africa/Johannesburg timezone
<a href="http://events.saip.org.za/internalPage.py?pageId=11&confId=14"><font color=#ff0000>SAIP2012 PROCEEDINGS AVAILABLE</font></a>

Biophysical Characterization of Biologics

12 Jul 2012, 16:20
IT 4-4

IT 4-4

Oral Presentation Track F - Applied Physics Biophysics


Dr Stoyan Stoychev (CSIR – Biosciences. Molecular Biomedical Technologies Platform)

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Abstract content <br> &nbsp; (Max 300 words)

The pharmaceutical industry is currently being transformed due to the emergence of biologics (bio-pharmaceuticals),which offer many advantages over conventional small molecule drugs including, higher efficacy, reduced side effects, and the potential to cure disease compared to treating symptoms. The size and complexity of biologics, in comparison to small-molecule drugs, has brought a unique set of challenges to manufacturers. Products have to undergo rigorous characterisation to facilitate transition through discovery into development, eventual commercialisation, and their ultimate intended therapeutic use. Achieving this goal is dependent on the availability of appropriate analytical tools to provide an array of chemical and physical information. This talk will focus on some of the techniques we are currently implementingfor reliable, high-resolution biochemical characterization of biologics, aimed at interrogating their sequence, structure and conformation.

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Primary author

Dr Stoyan Stoychev (CSIR – Biosciences. Molecular Biomedical Technologies Platform)

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