Speaker
Description
Previously it was reported that cell-surface Glucose Regulated Protein 78 (CS-GRP78), also termed heat shock protein A5 (HSPA5), could be a possible route for SARS-CoV-2 internalization. The binding site on the spike protein of SARS-CoV-2, which can recognize CS-GRP78, was predicted in a previous study. The spike glycoprotein of the SARS-CoV-2 bear many conserved motifs to the previously determined human coronavirus strains such as HKU1, 229E, NL63, OC43, MERS-CoV, and SARS-CoV. 2 However, we would like to emphasize that using a simple bioinformatics approach can suggest a possible role of the GRP78 in cross immunization against COVID-19. Additionally, different antiviral drugs have the potential to be SARS-CoV-2 inhibitors, thus can be used against COVID-19. These drugs are tested in silico at the beginning of the pandemic, and currently, some are approved against COVID-19.
Recent Publications
1. Ismail AM, Elfiky AA. SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic. Signal Transduction and Targeted Therapy. 2020;5(1):252.
2. Ibrahim IM, Abdelmalek DH, Elshahat ME, Elfiky AA. COVID-19 spike-host cell receptor GRP78 binding site prediction. Journal of Infection. 2020;80(5):554-62.
3. Elfiky AA. SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) recognition may be related to the immersed human coronaviruses. Frontiers in Pharmacology. 2020;11:1997.
4. Elfiky AA, Ibrahim IM, Ismail AM, Elshemey WM. A possible role for GRP78 in cross vaccination against COVID-19. Journal of Infection.
5. Elfiky AA. Natural products may interfere with SARS-CoV-2 attachment to the host cell. Journal of Biomolecular Structure and Dynamics. 2020:1-10.
