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SUMMARY:Fighting against COVID-19:  A computational biophysics approach
DTSTART;VALUE=DATE-TIME:20210322T134000Z
DTEND;VALUE=DATE-TIME:20210322T140000Z
DTSTAMP;VALUE=DATE-TIME:20260714T154148Z
UID:indico-contribution-6926@events.saip.org.za
DESCRIPTION:Speakers: Abdo Elfiky (Cairo University)\nPreviously it was re
 ported that cell-surface Glucose Regulated Protein 78 (CS-GRP78)\, also te
 rmed heat shock protein A5 (HSPA5)\, could be a possible route for SARS-Co
 V-2 internalization. The binding site on the spike protein of SARS-CoV-2\,
  which can recognize CS-GRP78\, was predicted in a previous study. The spi
 ke glycoprotein of the SARS-CoV-2 bear many conserved motifs to the previo
 usly determined human coronavirus strains such as HKU1\, 229E\, NL63\, OC4
 3\, MERS-CoV\, and SARS-CoV. 2 However\, we would like to emphasize that u
 sing a simple bioinformatics approach can suggest a possible role of the G
 RP78 in cross immunization against COVID-19. Additionally\, different anti
 viral drugs have the potential to be SARS-CoV-2 inhibitors\, thus can be u
 sed against COVID-19. These drugs are tested in silico at the beginning of
  the pandemic\, and currently\, some are approved against COVID-19.\n \nRe
 cent Publications \n1.   Ismail AM\, Elfiky AA. SARS-CoV-2 spike behavior 
 in situ: a Cryo-EM images for a better understanding of the COVID-19 pande
 mic. Signal Transduction and Targeted Therapy. 2020\;5(1):252.\n2.	Ibrahim
  IM\, Abdelmalek DH\, Elshahat ME\, Elfiky AA. COVID-19 spike-host cell re
 ceptor GRP78 binding site prediction. Journal of Infection. 2020\;80(5):55
 4-62.\n3.	Elfiky AA. SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) recogn
 ition may be related to the immersed human coronaviruses. Frontiers in Pha
 rmacology. 2020\;11:1997.\n4.	Elfiky AA\, Ibrahim IM\, Ismail AM\, Elsheme
 y WM. A possible role for GRP78 in cross vaccination against COVID-19. Jou
 rnal of Infection.\n5. Elfiky AA. Natural products may interfere with SARS
 -CoV-2 attachment to the host cell. Journal of Biomolecular Structure and 
 Dynamics. 2020:1-10.\n\nhttps://events.saip.org.za/event/213/contributions
 /6926/
LOCATION:Zoom Conference
URL:https://events.saip.org.za/event/213/contributions/6926/
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