8-12 July 2013
Africa/Johannesburg timezone
<a href="http://events.saip.org.za/internalPage.py?pageId=13&confId=32"><font color=#ff0000>SAIP2013 PROCEEDINGS AVAILABLE</font></a>

Cytogenetic analysis of Co-60 γ-radiation-induced chromosome damage and simulations using the Geant4 Monte Carlo toolkit

10 Jul 2013, 15:40
20m
Oral Presentation Track B - Nuclear, Particle and Radiation Physics NPRP

Speaker

Mr Hein Fourie (Stellenbosch University)

Main supervisor (name and email)<br>and his / her institution

Richard Newman, rtnewman@sun.ac.za
Department of Physics, Stellenbosch University

Apply to be<br> considered for a student <br> &nbsp; award (Yes / No)?

Yes

Would you like to <br> submit a short paper <br> for the Conference <br> Proceedings (Yes / No)?

Yes

Level for award<br>&nbsp;(Hons, MSc, <br> &nbsp; PhD)?

MSc

Abstract content <br> &nbsp; (Max 300 words)

The study investigates the determination and quantization of radiation damage on a cellular level and the replication of this energy deposition using the Geant4 Monte Carlo toolkit, developed for particle transportation simulations at CERN. The detection of micronuclei in binucleated cells was used to analyse the effects of the radiation. Results from micronucleus assays of rat brain endothelial and Chinese hamster ovary cells that have been irradiated with gamma rays, produced by a Co-60 teletherapy unit at iThemba LABS, are presented. Linear-quadratic dose response curves were determined for both cell lines and compared to those of other ionizing radiations. Additionally discussed are the simulated results of the Co-60 setup, irradiation and other relevant features offered by the Geant4 toolkit. Finally, prospective microdosimetric studies and simulations of damage caused by DNA-incorporated I-123 will be mentioned.

Primary author

Mr Hein Fourie (Stellenbosch University)

Co-authors

Prof. Kobus Slabbert (iThemba LABS) Mr Philip Beukes (iThemba LABS) Prof. Richard Newman (Stellenbosch University)

Presentation Materials

Peer reviewing

Paper