Breast cancer remains a formidable challenge in oncology despite significant advancements in treatment modalities. Conventional therapies such as surgery, chemotherapy, radiation therapy, and hormonal therapy have been the mainstay in managing breast cancer for decades. However, a subset of patient’s experiences treatment failure, leading to disease recurrence and progression. Therefore, this...
Breast cancer remains a major global public health concern due to its continuously rising incidence rate across a variety of demographics. An estimated 2.3 million new cases have made breast cancer higher in incidence rate than the commonly reported lung cancer. Furthermore, women in developing countries have higher mortality rates, 15.3 compared to 11.3 per 100 000 but a much lower incidence...
Photodynamic therapy (PDT) has emerged as a promising alternative or adjunct modality for the treatment of breast cancer. PDT relies on the activation of a photosensitizer (PS) by red or near-infrared light, resulting in the generation of reactive oxygen species (ROS) that induce localized tumor cell damage. Naturally derived tetrapyrrolic PSs have attracted considerable interest due to their...
Abstract
Photodynamic therapy employing Hypericin has gained attention as a potential alternative for breast cancer treatment, yet its clinical utility remains limited by poor solubility, low selectivity, and non-specific cellular uptake. To address these challenges, we developed a targeted nanoplatform integrating green-synthesized gold nanoparticles (AuNPs), Hypericin, and monoclonal...
Abstract: Photodynamic therapy (PDT) has increasingly been recognised as a promising biomedical strategy for the management of diverse cancers, offering spatial and temporal selectivity compared with conventional chemotherapeutic approaches. However, its therapeutic success is critically dependent on the phototoxic potential of the photosensitiser (Ps) employed and its ability to localise...
Glory Kah and Heidi Abrahmse*
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein Campus. Post Office Box 17011, Johannesburg 2028, South Africa
*Correspondence: Heidi Abrahamse. Email: habrahamse@uj.ac.za
Abstract. Lung cancer remains a leading cause of cancer-related mortality worldwide, largely due to therapeutic resistance mediated by lung...
Silver nanoparticles (AgNPs) offer potent oncological potential via tunable SPR, yet conventional toxicity remains a challenge. This study evaluates biogenic synthesis and photoactivation as safer, targeted alternatives for MCF-7 and MDA-MB-231 breast cancer cells. Specifically, plant-mediated (biogenic) and chemically synthesized AgNPs were evaluated as wavelength-activated nanotherapeutics...
In the present study, a series of magnetic nanoparticles (MNPs) belonging to the spinel ferrite family (XFe2O4 where X = Mg, Cu, Co, Mn) and hexaferrite structures (Ba2Co2Fe12O22 and BaFe12O19) were synthesized using sol-gel and modified co-precipitation methods. The research aims to optimize the structural and physical properties for localized cancer treatment via magnetic hyperthermia. The...
Early detection of brain tumors is essential for improving clinical outcomes and guiding effective therapeutic interventions. Magnetic Resonance Imaging (MRI) plays a central role in neuro-oncology due to its non-invasive nature and superior soft-tissue contrast. Recent developments in MRI technology, driven by advances in medical physics and biophysical modeling, have significantly improved...
Medical biophysics continues to expand the understanding of how physical forces and radiation interact with biological systems. While traditional radiobiology focuses mainly on DNA damage and biochemical pathways, the mechanical responses of cells to ionizing radiation remain relatively unexplored. This study proposes a novel approach that investigates how radiation exposure alters the...
This talk is is actually this month's PHYSICS MATTERS presentation of the American Physical Society (APS) Forum on International Physics (FIP).
This talk has its [separate registration and Zoom link][1]..
Abstract:
Medical physics (MP) has been an indispensable and strategic stakeholder in the delivery of healthcare in Africa, with immense support to diagnostic radiology (DR),...
