Speakers
Description
In the present study, a series of magnetic nanoparticles (MNPs) belonging to the spinel ferrite family (XFe2O4 where X = Mg, Cu, Co, Mn) and hexaferrite structures (Ba2Co2Fe12O22 and BaFe12O19) were synthesized using sol-gel and modified co-precipitation methods. The research aims to optimize the structural and physical properties for localized cancer treatment via magnetic hyperthermia. The structural and morphological characteristics were investigated using X-ray diffraction (XRD) and electron microscopy (FE-SEM/TEM), confirming the formation of pure crystalline phases with tailored nanostructures. The optical properties were investigated using UV-visible spectroscopy, revealing a significant dependence of the energy bandgap on the chemical composition and ion substitution. The calculated bandgap values, along with the magnetic parameters obtained from VSM, were correlated to the induction heating performance. Under an alternating magnetic field (150–300 kHz), the specific absorption rate (SAR) values reached up to 350 W/g, particularly in Mn-substituted copper ferrites.
Furthermore, the results indicate that the prepared MNPs, especially the optimized barium hexaferrite (Ba2Co2Fe12O22), exhibit a high potential for inhibiting tumor cell growth when activated by an external magnetic field. These findings highlight the potential of these optimized ferrites as high-performance agents for magnetic hyperthermia and multi-functional biomedical platforms, offering a promising approach for non-invasive thermal therapy.
Keywords:
Magnetic Hyperthermia; Spinel Ferrites; Hexaferrites; substitution; Optical Properties; Bandgap; Specific Absorption Rate (SAR); Tumor Treatment.
