Conveners
Structural biology II
- Bryan Trevor Sewell (University of Cape Town)
The method of choice for obtaining detailed, high resolution structural information macromolecules is X-ray crystallography. The magnitude of X-ray scattering from the electron cloud around an atomic nucleus is related to the Z number of that element, i.e., the more electrons an atom has, the better it will scatter X-rays. Due to this it is very challenging in theory and practice to determine...
Tuberculosis (TB), the world’s leading cause of death by infectious disease, is increasingly resistant to current first line antibiotics. The bacterium Mycobacterium tuberculosis that causes TB can survive low-energy conditions, which allows infections to remain dormant and decreases their susceptibility to many antibiotics. Bedaquiline was developed in 2005 from a lead compound identified in...
Nuclear Magnetic Resonance (NMR) spectroscopy is an enabling technology capable to provide information and answers to biological problems that cannot be obtained by other means. NMR studies, both in solution and in the solid-state, can inform on the structure of a macromolecule in many different environments ranging from buffered solutions to intact cells, can provide insight into dynamic...
Oral presentation
The transfer of large toxin and antibiotic resistance genes in the pathogenic bacteria Clostridium perfringens is mediated by the tcp conjugation locus. Functional genetic analysis of the tcp locus of the paradigm plasmid pCW3 has revealed that its gene products assemble into a multi-protein complex that distantly resembles a type 4 secretion system (T4SS).
Here, I will provide a brief...
