Conveners
Computational biology
- Lawrence Norris (National Society of Black Physicists)
Cellular transformation is associated with dramatic changes in gene expression, but it is difficult to determine which regulated genes are oncogenically relevant. Here we describe Pheno-RNA, a general approach to identifying candidate genes associated with a specific phenotype. Specifically, we generate a “phenotypic series” by treating a nontransformed breast cell line with a wide variety...
LHCII — the main light-harvesting complex of plants and green algae — is the most abundant membrane protein on earth. Here, we investigate theoretically the effect of exciton-plasmon coupling on LHCII’s fluorescence quantum yield and compare our modelling results to experimental data where plasmon-enhanced fluorescence has been reported in an LHCII–gold nanorod system. One of the models relies...
Human schistosomiasis has heavily plagued the destitute of various tropical and sub-tropical countries of the world, particularly in sub-Saharan Africa and South America, with devastating effects in various health and economic areas [1]. Globally, the burden of schistosomiasis has been controlled by using a single chemotherapeutic drug, Praziquantel [2]. However, the drug has recently...
Praziquantel (PZQ) has been the drug of choice for the treatment of schistosomiasis for more than 30 years. Resistance to this drug, however, has been documented severally in recent years, hence the need for effective alternatives. This study investigated the effect of an inhibitor (dynarrestin) on the identified Schistosoma mansoni axonemal dynein intermediate protein (SmAxDynIC), a potential...
Abstract
Electrostatic interaction between parallel charged palettes can be considered as a starting point to investigate the properties of complexes biological mater like AND-protein interactions. In this work, we solve numerically the Poisson Boltzmann equation to calculate the electrostatic potential between charged palettes immerged in aqueous solution containing monovalent salt. The...
