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SUMMARY:Predicting human epidermal melanin concentrations for different sk
 in tones
DTSTART;VALUE=DATE-TIME:20110714T061500Z
DTEND;VALUE=DATE-TIME:20110714T063000Z
DTSTAMP;VALUE=DATE-TIME:20260911T101757Z
UID:indico-contribution-5219@events.saip.org.za
DESCRIPTION:Speakers: Jacoba Smit (CSIR)\nIn the past 50 years lasers has 
 found numerous applications in medicine. One of their advantages is their 
 use for minimalistic or non-invasive diagnosis and treatment. Often that m
 eans light penetration through skin and the correct dose required relies o
 n accurate information regarding the skin’s optical properties. Light ab
 sorption in the epidermal layer is a major factor in determining the laser
  light fluence that reaches the deeper skin levels. Darker skin has an epi
 dermal melanin volume fraction about twice that of lighter skin. Due to me
 lanin absorption\, less laser light reaches the deeper skin layers in dark
  skin tones. Laser-tissue interaction modelling software can correct for t
 his by adapting the dose applied to the skin. To correctly apply such soft
 ware it is important to characterise the skin in terms of skin tone with a
 n easy and reliable method. Measuring the melanin content of the skin is t
 he best method\, but it needs to be done non-invasively. However\, access 
 to samples of all skin types is often limited and skin-like phantoms are u
 sed instead. The objective of this study is to compare experimentally meas
 ured absorption features of liquid skin-like phantoms representing Skin Ty
 pes I to VI with computational simulated skin from the Realistic Skin Mode
 l (RSM) part of the ASAP® software from Breault Research. Skin-like phant
 oms were prepared by adding Intralipid (20% fat emulsion) to samples of in
 creasing melanin concentration at pH ~ 7. UV-VIS transmittance spectra of 
 the samples were measured over the wavelength range 370 to 900 nm and comp
 ared to simulated results from ASAP® using the same optical parameters. E
 xperimental and computational results indicated that at shorter wavelength
 s melanin absorption displayed non-monotonic features that may allow for m
 ore accurate ways of determining melanin concentration and therefore the e
 xpected absorption through the epidermal layer. This suggests that the pha
 ntoms may be able to represent optical characteristics of real skin.\n\nht
 tps://events.saip.org.za/event/7/contributions/5219/
LOCATION: Acro3
URL:https://events.saip.org.za/event/7/contributions/5219/
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