The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a validated therapeutic target for Type 2 diabetes mellitus due to its role in local regeneration of active glucocorticoids. Current inhibitors are often limited by their constrained chemical diversity, moderate potency, and off-target effects. The therapeutic potential of steroidal pregnanes in diabetes and metabolic disorders...
Preparing future biophysicists requires approaches that connect foundational biological principles with modern computational tools. Our work introduces a Generative‑AI–enhanced framework for teaching bioinformatics, designed to strengthen students’ computational reasoning, data literacy, and engagement with cardiovascular‑related biological systems. This model emphasizes ethical and effective...
Quantifying how temperature and ionic strength jointly determine the elastic properties of double-stranded DNA remains a central challenge in molecular biophysics. Although individual temperature or salt dependent trends have been measured, a unified, mechanistic map across high-salt and elevated-temperature regimes is still lacking. Here, we use the oxDNA2 coarse-grained model to compute a...
