Helicases are essential and ubiquitous enzymes, playing a key role in a variety of processes in DNA and RNA metabolism. A subset of helicases play specialised and specific functions by resolving/remodelling a variety of atypical DNA structures, such as G-quadruplexes, triplexes, Holliday junctions, as well as displacement loops (D-loops and R-loops): among those a major role is played by the...
Under conditions of extreme acidity, the lysine-specific permease, LysP, not only mediates the import of L-lysine it also interacts with the transcriptional regulator, CadC, to activate expression of the cadAB operon. This operon encodes the lysine decarboxylase, CadA, which converts lysine to cadaverine while consuming a cytoplasmic proton, and the antiporter, CadB, which exports protonated...
Abstract
Kristen rat sarcoma (KRAS) is an oncogene responsible for almost 20% of all human cancers and over 90% of pancreatic ductal adenocarcinoma. To date, only two covalent drugs are approved by the United States food and drug administration (FDA) for the treatment of KRAS G12C related cancers. However, their effectiveness is limited in cancers driven by non-G12C KRAS mutations as...
