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SUMMARY:We are all different: Modeling key individual differences in physi
 ological systems
DTSTART;VALUE=DATE-TIME:20260324T130500Z
DTEND;VALUE=DATE-TIME:20260324T140500Z
DTSTAMP;VALUE=DATE-TIME:20260426T030123Z
UID:indico-contribution-10334@events.saip.org.za
DESCRIPTION:Speakers: Anita LAYTON (University of Waterloo)\nMathematical 
 models of whole-body dynamics have advanced our understanding of human int
 egrative systems that regulate physiological processes such as metabolism\
 , temperature\, and blood pressure. For most of these whole-body models\, 
 baseline parameters describe a 35-year-old young adult man who weighs 70 k
 g. As such\, even among adults those models may not accurately represent h
 alf of the population (women)\, the older population\, and those who weigh
  significantly more than 70 kg. Indeed\, sex\, age\, and weight are known 
 modulators of physiological function. To more accurately simulate a person
  who does not look like that "baseline person\," or to explain the mechani
 sms that yield the observed sex or age differences\, these factors should 
 be incorporated into mathematical models of physiological systems. Another
  key modulator is the time of day\, because most physiological processes a
 re regulated by the circadian clocks. Thus\, ideally\, mathematical models
  of integrative physiological systems should be specific to either a man o
 r woman\, of a certain age and weight\, and a given time of day. A major g
 oal of our research program is to build models specific to different subpo
 pulations\, and conduct model simulations to unravel the functional impact
 s of individual differences.\n\nhttps://events.saip.org.za/event/272/contr
 ibutions/10334/
LOCATION:
URL:https://events.saip.org.za/event/272/contributions/10334/
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