BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Physicochemical Characterisation and Antibacterial Activities of C
 erium Oxide Nanoparticles
DTSTART;VALUE=DATE-TIME:20260327T095000Z
DTEND;VALUE=DATE-TIME:20260327T101000Z
DTSTAMP;VALUE=DATE-TIME:20260426T030124Z
UID:indico-contribution-10327@events.saip.org.za
DESCRIPTION:Speakers: Fezile Motsoene (University of Johannesburg)\nDiabet
 ic wounds represent a complex biophysical microenvironment characterised b
 y sustained inflammation\, excess reactive oxygenated species\, impaired f
 ibroblastic proliferation\, and prevalent bacterial infections\, particula
 rly P. aeruginosa. Dysregulated redox homeostasis and altered cellular res
 ponses in diabetic tissue significantly compromise wound healing. Although
  conventional therapies\, including hormonal regulation\, pressure reducti
 on\, wound debridement\, and antibiotic treatments\, have long served as t
 he foundational approach to the management of diabetic wounds\, the increa
 sed disease recurrence and heightened bacterial progression have highlight
 ed the limitations of traditional methods. Therefore\, this study evaluate
 s the biophysical and bacterial interaction between green-synthesised ceri
 um oxide nanoparticles (CeO2 NPs) and both P. aeruginosa bacterial and mam
 malian wounded cells. The comprehensive physicochemical characterisation w
 ill be used to demonstrate the band gap energy\, hydrodynamic size\, morph
 ological properties\, and redox activity. Additionally\, the biophysical e
 valuation\, including antibacterial assays against P. aeruginosa\, will de
 monstrate a concentration-dependent response mediated through membrane int
 eractions. Moreover\, the application of CeO2 NPs in fibroblasts will enha
 nce the viability and proliferative responses under oxidative stress condi
 tions\, suggesting restoration of redox equilibrium and improved metabolic
  activity. These findings support the potential integration of complementa
 ry bioenergetic modulation strategies in future investigations. Furthermor
 e\, the collective findings will enhance the biophysical understanding of 
 nanobio interactions in diabetic wounds while advocating the advancement o
 f redox-active plant-derived nanoparticles designed for resource-constrain
 ed environments.\n\nhttps://events.saip.org.za/event/272/contributions/103
 27/
LOCATION:
URL:https://events.saip.org.za/event/272/contributions/10327/
END:VEVENT
END:VCALENDAR