Biophysics in Africa - 2023

Session

Molecular Biophysics

26 Sep 2023, 11:00

Conveners

Molecular Biophysics: Molecular Biophysics

• Tjaart Krüger (University of Pretoria)

Contribution list Timetable

89. Overexpression, purification, and characterization of the Hsp70.14 protein towards the discovery and development of new anti-cancer compounds

Mr Tshepang Ndaba (University of Johannesburg)

26/09/2023, 11:00

Physical Biochemistry / Molecular Biophysics

Oral Presentation

Cancer remains one of the leading causes of death, with over 2 million cases worldwide. New therapeutic approaches are therefore under constant development, aimed at eliminating various pathways/mechanisms utilized by cancerous cells. Previous studies have investigated the molecular interaction between the Heat shock protein 70.14 (Hsp70.14) and the RING finger domain of Retinoblastoma binding...

88. Recombinant expression and biophysical characterization of NAD-binding domain of S. mansoni Glyceraldehyde 3-phosphate dehydrogenase.

Ms Kagiso Motlhatlhedi (University of Johannesburg)

26/09/2023, 11:30

Physical Biochemistry / Molecular Biophysics

Oral Presentation

Schistosomiasis is a devastating parasitic disease affecting over 200 million people globally and has the highest morbidity and mortality in sub-Saharan Africa. Praziquantel (PZQ) has been the only drug used to treat all schistosome infections because it is readily available, cost-effective, and has minimal side effects. Recent studies have shown that PZQ-resistant strains are emerging due to...