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SUMMARY:Evolutionary cues in the physicochemical description of proteomes
DTSTART;VALUE=DATE-TIME:20210322T142000Z
DTEND;VALUE=DATE-TIME:20210322T144000Z
DTSTAMP;VALUE=DATE-TIME:20260711T213328Z
UID:indico-contribution-6953@events.saip.org.za
DESCRIPTION:Speakers: Eloy Vallina (Stockholm University)\nWith the glarin
 g exception of highly conserved binding interfaces\, protein surfaces tend
  to be regarded as variable regions of hydrophilic character\, subjected o
 nly to soft evolutionary pressures. However\, in crowded cellular conditio
 ns\, electrostatic interactions between surfaces take on a critical role i
 n modulating protein interactivity\, with downstream consequences for prot
 ein stability\, mobility and solubility. In this context\, surface net cha
 rge density stands out as the single most important determinant of protein
  mobility inside the cell. Moreover\, in _E. coli_\, proteins organise aro
 und a moderately negative net charge density value\, which ensures cytosol
 -wide colloidal stability: molecules keep away and remain highly mobile mo
 st of the time\, but close-range interactions are allowed upon small therm
 al fluctuations. Our results show that\, across organisms\, the average va
 lue at which this Goldilocks situation is achieved varies\, often dependin
 g on niche and intracellular conditions: extreme lifestyles—archaeal hal
 ophiles and endosymbiotic bacteria— can be mapped to different net charg
 e density values. By combining net charge density with other simplistic ph
 ysicochemical observables\, derived from sequence data alone\, we can show
  that the profile of different organism groups changes consistently with t
 he taxonomical hierarchy. Thus\, we propose that previously unrecognised e
 volutionary cues can be revealed by inexpensive physicochemical profiling\
 , and that these have the potential to contribute complementary informatio
 n to state-of-art phylogenetic inference.\n\nhttps://events.saip.org.za/ev
 ent/213/contributions/6953/
LOCATION:Zoom Conference
URL:https://events.saip.org.za/event/213/contributions/6953/
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