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SUMMARY:Inhibition of Lung Cancer Migration and Invasion Using a Gold Nano
  Photosensitizer Conjugate.
DTSTART;VALUE=DATE-TIME:20210726T093000Z
DTEND;VALUE=DATE-TIME:20210726T094500Z
DTSTAMP;VALUE=DATE-TIME:20260915T062050Z
UID:indico-contribution-7196@events.saip.org.za
DESCRIPTION:Speakers: Anine Crous (University of Johannesburg)\nDespite ad
 vances in cancer treatment\, lung cancer remains one of the leading causes
  of cancer deaths worldwide. Lung cancer can spread through the blood and 
 lymphatic systems\, as well as infiltrate healthy tissues underlying the l
 ung\, resulting in both distant and local metastasis. The most common caus
 es of death are cancer metastasis and the threat of secondary tumours. The
  ability of cells to invade\, which is largely controlled by cell motility
 \, is an essential aspect of metastases. Photodynamic therapy (PDT)\, a mi
 nimally invasive cancer treatment\, is based on the concept of light stimu
 lation of a photosensitizing agent at a certain wavelength\, which\, combi
 ned with an optimum energy density of light activation\, induces the photo
 sensitizer (PS) to reach their triplet state\, where oxidants causing tumo
 ur cell death can form in the presence of molecular oxygen. Due to their p
 hysicochemical and optical properties\, gold nanoparticles have been shown
  to improve the effectivity of PDT by increasing the loading potential of 
 the PS within cancer cells\, are biocompatible and non-toxic\, and give im
 proved permeability and retention. The use of gold nanoparticles in nano-m
 ediated PDT has been shown to cause lung cancer cell death. Several physio
 logical studies\, including migration\, cell cycle analysis and the extrac
 ellular matrix cell invasion assay were carried out in this study to deter
 mine whether PDT using a gold nano sensitizer inhibits lung cancer migrati
 on and invasion. The results show that nano mediated PDT treatment of lung
  cancer inhibits lung cancer migration and invasion\, causes cell cycle ar
 rest\, and reduces lung cancer proliferative abilities\, elaborating on th
 e efficacy of nano mediated PDT treatment of lung cancer.\n\nhttps://event
 s.saip.org.za/event/206/contributions/7196/
LOCATION:North-West University Potchefstroom Campus
URL:https://events.saip.org.za/event/206/contributions/7196/
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